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Nicotine exerts anti-inflammatory and immune-modulating effects through a mechanism dependent on the alpha7 nicotinic receptor31 and has been shown to suppress neuroinflammation and disease severity in experimental autoimmune encephalomyelitis.3235 The lower HR of unfavourable outcomes among past snuff users than among current snuff users in our main analysis may be explained by the proportion of participants who replaced smoking with snuff use after the first clinical symptoms of the disease

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But for the first time in 20 years, Rocky Ryan can resist the urge to smoke a cigarette

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