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Tobacco companies have increasingly indicated their support for such laws, but they often simultaneously support and help to develop policies that weaken the impact of other effective tobacco control laws

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This work suggests the potential for substantial reduction of select harmful smoke constituents without concurrent broad sacrifices to other cigarette design parameters

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The working group also used GRADE to determine the certainty of the evidence and strength of the recommendation (Box 1).21 Appendices 47 (available at www.cmaj.ca/lookup/doi/10.1503/cmaj.241584/tab-related-content) provide the evidence-to-decision frameworks the task force used to develop recommendations

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