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1 2 3 4 5 "Adolescents and Tobacco: Risk and Protective Factors"

It was significantly more effective compared to a pod e-cigarette, although puffing behavior did not differ significantly between e-cigarettes, likely due to device design 26,55

Although it is not entirely clear whether it is nicotine per se, the major active element in cigarette smoke and the key ingredient of electronic nicotine delivery devices, nicotine itself has now been shown to enhance airway hyperresponsiveness (12, 14, 19, 22, 23)

The nicotine in e-cigarettes can raise blood pressure and heart rate, which may cause cardiac challenges, especially in people who already have cardiovascular problems