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Henrot P, Dupin I, Schilfarth P, Esteves P, Blervaque L, Zysman M et al

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2Chest Pain If you smoke and have chest pain that worsens when you laugh, cough or breathe deeply, it could be a sign of heart disease such as arteriosclerosis (hardening of the arteries) or atherosclerosis, a type of arteriosclerosis in which a buildup of plaque in your blood vessels can lead to a dangerous clot

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For example, research published in Nature Medicine demonstrated that nicotine stimulates the vagus nerve, and, by extension, nicotinic receptors, reducing inflammatory cytokine production in models of sepsis