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Goel and colleagues (2018) quantified nicotine yields in the smoke of little cigars and filtered cigars (collectively called small cigars because of the lack of standard definitions and inconsistent classification of both products) and compared them to cigarettes

The independent variables were demographics, knowledge scores about the harms of cigarette smoking, rules about smoking at home, exposure to information about the dangers of smoking, and exposure to advertisements

On the other hand, dehydration decreases urine output, which may decrease excretion

Altria's deal to take a 35% stake in Juul, valued the firm at more than $38bn - more than double the $16bn valuation settled on during its most recent financing round in July

Lesions that inactivate or downregulate tumor suppressor genes (the products of which, by definition, suppress tumorigenesis) and lesions that upregulate or inappropriately activate oncogenes (the products of which contribute to tumorigenesis) encourage the development of lung cancer