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This finding aligns with previous research by Alzoubi et al., who reported significant reductions in IL-10 levels in lung tissue after 1 week of exposure, though no corresponding changes were detected in BALF (44)

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Taken together with the non-significant tendency for higher increases where subjects had less weight gain, and higher increases when adjusted for weight gain in two studies, the results suggest a role of diet and weight gain in mitigating the magnitude of the increase

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The smokers themselves used to make them at home