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1994 Epidemiology of Lung Cancer Samet J (ed.) New York: Marcel Dekker, Inc pp 71108 Wynder E, Graham E

The exposure ranged from 1 cigarette to 60 cigarettes smoked per day, with the 85th percentile of exposure in the exposed group being 26.25 cigarettes smoked per day

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Modified Risk Tobacco Products The modified risk tobacco product (MRTP) pathway is outlined in the 2009 Family Smoking prevention and Tobacco Control Act [and] allows companies to submit applications for the FDA to evaluate whether a tobacco product may be sold or distributed for use to reduce harm or the risk of tobacco-related disease associated with commercially marketed tobacco products. The FDA maintains that the products authorized to be marketed with this claim are neither safe nor FDA-approved