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Abbreviations ACh acetylcholine ACE2 angiotensinconverting enzyme 2 ANG(17) angiotensin 17 ARDS acute respiratory distress syndrome AUD alcohol use disorder CCL2 chemokine L2 CNS central nervous system COVID19 coronavirus disease of 2019 IL interleukin nAChRs nicotinic cholinergic receptors SARSCoV2 severe acute respiratory syndrome coronavirus 2 SUD substance use disorder Introduction The worldwide toll exacted by a singlestranded RNA virus, the severe acute respiratory syndrome coronavirus 2 (SARSCoV2), leading to the coronavirus disease of 2019 (COVID19), is a wakeup call to better understand the role of viruses and infectious elements and to come up with an improved strategy for collective responses to pandemics

doi:10.1159/000088905