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Earnings per share (continued) Earnings per share calculations are based upon the following: Reported Adjusted Headline Basic Diluted Basic Diluted Basic Diluted Year ended 31 December 2025 Earnings m 7,677 7,677 7,743 7,743 7,169 7,169 Shares m 2,187 2,199 2,187 2,199 2,187 2,199 Per share p 351.0 349.1 354.0 352.1 327.8 326.0 Year ended 31 December 2024 Earnings m 3,026 3,026 8,066 8,066 2,276 2,276 Shares m 2,214 2,225 2,214 2,225 2,214 2,225 Per share p 136.7 136.0 364.3 362.5 102.8 102.3 Adjusted diluted earnings per share are calculated by taking the following adjustments into account (see pages 25 to 30): Items presented below are net of tax and non-controlling interests when applicable
Potential Adverse Reactions Naltrexone can have some drawbacks, including the following: Nausea Vomiting Injection site rashes or swelling (hypersensitivity reaction) Muscle cramps Fainting Dizziness Sleep disturbances Drug interactions (including with over-the-counter drugs or herbal supplements) Decreased appetite or anorexia
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