The summary must establish that, based on the totality of publicly available scientific evidence (including evidence from well-designed studies conducted in a manner which is consistent with generally recognized scientific procedures and principles), there is significant scientific agreement among experts qualified by scientific training and experience to evaluate such claims, that the claim is supported by such evidence
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Following the case-cohort analysis method, we created a subcohort which consisted of the participants who were free of dementia in the remaining set and one-third randomly selected participants who developed dementia during follow-up, since the training and test sets split was 2:1
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