However, as IVW can be sensitive to heterogeneity and horizontal pleiotropy, we performed additional sensitivity analyses using complementary MR methods, including MR-Egger regression, the weighted median method, and the weighted mode estimator, to evaluate the robustness of our findings and to account for potential violations of the MR assumptions
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This association of CRF levels and mortality risk was also observed across the entire age spectrum, including septuagenarians and octogenarians, and remained consistently inverse, independent, and graded across men, women, and all races [51]
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