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Patients and methods Patients cohort and evaluated clinical features Seventy-five patients, 44 index-cases and 31 relatives, with cEDS were evaluated from 2010 to 2019 in a tertiary referral center for the diagnosis and management of HCTDs (i.e., Ehlers-Danlos Syndrome and Inherited Connective Tissue Disorders Outpatient Clinic (CESED) at the Spedali Civili University Hospital of Brescia