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DPP4 is mostly expressed in various alveolar cells, including epithelial, endothelial, macrophages, and other immune cells in the submucosal region of airway epithelium and lymphoid aggregates, but not in bronchial epithelial cells [310]

4 Cigarette smoke is well known as a potent inducer of chronic pulmonary inflammation, as evidenced by significant immune cell infiltration, and is also a major environmental risk factor for IBD

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