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van Osch FH, Jochems SH, van Schooten FJ, Bryan RT, Zeegers MP (2016) Quantified relations between exposure to tobacco smoking and bladder cancer risk: a meta-analysis of 89 observational studies

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from the 1970s onwards, the view was growing among some tobacco researchers and clinicians that nicotine and nicotine addiction were not, in fact, directly responsible for the death and disease caused by smoking When and where did the concept of tobacco harm reduction emerge