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Over time, the effects of tobacco use have been shown to do harm to virtually all of the tissues and metabolic functions in the body

It used to puzzle me at first

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Some folks even feel queasy

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When he left the confines of the small screen for big-screen pastures, Clooney transcended mere stardom to become one of the most prominent actors of his era, emulating the devil-may-care nonchalance of a Cary Grant or Clark Gable, while at the same time becoming an Academy Award-winning performer, risk-taking director, and socially-conscious activist