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"The message from this research is that women should quit smoking before becoming pregnant, or very early on, to reduce the chance of having a baby with a serious and lifelong physical defect." Co-author, Professor Charles Rodeck, UCL Institute for Women's Health, added: "The results of this research are of the greatest significance for the health of mothers and babies and for public health policy

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10 The underlying mechanisms likely involve diverse constituents of smoke, including nicotine, oxygen free radicals, and carbon monoxide, which may affect various targets, such as the mucus layer, gut microbiota, immune cells, gastrointestinal motility, and microvasculature

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