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Histone modification is also involved in smoking-induced emphysema and apoptosis [68,69,70]

Because no single biomarker is available that can be used alone to predict the reduction in harm from smoking (ventilated vs nonventilated cigarettes), a panel of biomarkers of exposure to carcinogens and lung toxicants, markers of oxidative damage and inflammation should be measured in lung, blood, or/and urine

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The non-nicotine components of ENDSflavorings, glycerol or propylene glycol, and metals (from the heating coil)have been shown to cause heart and lung toxicity in animal and in vitro studies