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Driver gene mutations and targeted therapy As compared to smokers with lung cancer, EGFR mutations occur at a high frequency among LCNS patients, the majority of which can be treated with oral targeted EGFR tyrosine kinase inhibitors (TKIs), osimertinib, as a first line treatment for such patients in advanced stages of disease [89]

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Other carcinogens in tobacco smoke are radioactive isotopes, including lead-210 and polonium-210

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