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14 Long-term effects Regular, long-term use of fentanyl may cause: dependence less effective pain relief (tolerance) increased risk of getting sick from viruses and infections sleep problems reduced bone density and higher risk of breaking bones heightened sensitivity to pain (opioid-induced hyperalgesia) impacts on hormone levels leading to reduced sex drive, infertility, erectile dysfunction, or menstrual cycle changes

Specifically, nicotine dependence includes: Tolerance to nicotine by needing more and more of the drug to feel normal as well as the absence of nausea and dizziness with repeated use

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