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History [edit] The brand was launched in 1981 by Philip Morris USA as a "low-nicotine" brand in the United States which the company dubbed as "de-nic"

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This approach allowed us to systematically identify all relevant studies indexed in PubMed up to 31 May 2022, and we extracted relevant data on risk of smoking, including study characteristics, following a pre-specified template (Supplementary Table 2)