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Smoking, nicotine, and ACE2 On one hand, it is proposed that smoking or nicotine may upregulate the detrimental angiotensinconverting enzyme (ACE) but downregulate the compensatory ACE2/ANG(17) receptor axis and hence contribute to cardiovascular and pulmonary diseases [53, 54, 55]

Proper tobacco retailer point-of-sale signage is important because it will communicate and inform customers about the minimum sales age law and remind employees to verify age before making the sale of tobacco products

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