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reported an increase in both M1 and M2 macrophage proportions in the lungs of COPD patients, correlating with smoking history and disease severity

Another study on human organotypic oral epithelial cultures showed that IQOS, compared to CS, yielded less cytotoxicity (significant after 48 h post-exposure), secretion of proinflammatory mediators, and gene expression perturbations related to apoptosis, necroptosis, senescence, xenobiotic metabolism, and oxidative stress 58

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