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A person might drop two quarters into a forgotten cigarette machine from America's past, hear the mechanical resistance give way, and receive a fresh pack along with a few coins back in change

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Long-term animal studies for assessment of toxicity and carcinogenesis are not ideal models because of the requirement for long-term intensive smoke exposure, the length of time required to induce visible tumors, and the lack of an established robust animal model for cigarette smoke-mediated carcinogenesis

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market within two years of launch