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You can cough up blood during any stage of lung cancer

Criticism: no comparison with smoking However, the report's conclusions are sharply criticised by a number of researchers in the field of tobacco harm, addiction and behavioural sciences

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This may be explained by the possible DNE and GOF effects of non-disruptive mutant p53 proteins that lead to increased proliferation, metastasis and chemo-resistance, whereas disruptive p53 mutations are unlikely to exert DNE and GOF effects [167]

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