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All-cause and cause-specific mortality risk was assessed according to baseline smoking status (current, former, never) and menthol flavor status (menthol, non-menthol) of the cigarette brand smoked for the longest period

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Perkins KA, Grobe JE, Fonte C, Goettler J, Caggiula AR, Reynolds WA et al (1994a)

Smoking accelerates renal cystic disease and worsens cardiac phenotype in Pkd1-deficient mice

For example, the 20 counties with the highest rates of smoking-related cancers in 2016 had an average smoking prevalence nearly twice the overall average (32% versus 18%) and all 20 counties were in Kentucky