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An industry lobbyist told the committee that the FDA has created an untenable marketplace by rejecting more than 99% of applications submitted by companies

Its consumption can cause the brain to crave more and more of the substance, although it is important to note that cigarette addiction works in different ways than addiction to other drugs

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The ROS is a single summary of the effect of smoking on the outcome, with higher positive ROSs corresponding to stronger and more consistent evidence and a higher average effect size of smoking and a negative ROS, suggesting that, based on the available evidence, there is no significant effect of smoking on the outcome after accounting for between-study heterogeneity

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