This cellular damage activates hepatic stellate cells (HSCs), which are key players in liver fibrogenesis, contributing to the deposition of extracellular matrix proteins and the progression of fibrosis [8,9,10]
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Ethical approval and consent to participate The study was approved by the local medical authority (Preventive Medicine)
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RING-edited cells exhibited mutation-dependent alterations in proliferation relative to parental controls, with some clones showing reduced growth and others demonstrating increased proliferative capacity