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Discussion This study on a cohort of 75 molecularly proven cEDS patients aimed to validate the revised diagnostic criteria and explore the multisystemic involvement of the disorder by comparing types and incidences of the numerous clinical manifestations at different ages and with those observed in other EDS subtypes, in order to delineate natural history and assist differential diagnosis

The tar and nicotine in cigarettes bond to tooth enamel, leaving behind yellow, brown, and sometimes black discoloration that regular brushing alone cannot fully remove

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