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When participants who had no early-life tobacco exposure and a low polygenic risk score were compared to those with a high polygenic risk score, an alarming escalation of risk for developing T2D was seen in utero, in childhood and in adolescence, said Eckel, a professor emeritus of medicine in the Division of Endocrinology, Metabolism and Diabetes and the Division of Cardiology and the Charles A

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Therefore, high plasma uric acid concentrations might be protective in situations characterized by an increase of cardiovascular risk and oxidative stress, such as smoking [14], and a reduction of its level, which increases susceptibility to oxidative damage and accounts for the excessive free radical production [16]

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