The AEs that occurred more frequently in the varenicline group than in the placebo group were nausea (49 [19.9%] vs 19 [12.3%]), flatulence (17 [6.9%] vs 6 [3.9%]), and abnormal dreams (16 [6.5%] vs 5 [3.3%]) (Additional file 1: Table S5)
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Only a few studies have examined the effect of cumulative smoking on the risk of diabetes [15-17]
Smoking may be making pain worse and increasing the likelihood of high-impact chronic pain
