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For all the choice and convenience, the first wave of vaping brands lacked something many smokers craved: a heightened physical sensation when inhaling and greater strength

Beyond Pleasure: Aversion Pathways While the mesolimbic dopamine system mediates nicotines rewarding effects, nicotine also activates the medial habenulainterpeduncular nucleus (MHbIPN) circuit, which produces aversive sensations such as nausea at high doses

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