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In males, nicotine affects the testes where prolonged exposure changes the morphology of spermatogenic cells, reduces sperm production, decreased steroidogenesis and inhibits spermatogenesis resulting in decreased sperm counts, poor sperm motility and increased levels of DNA damage [20, 21]

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As clearly shown in the results (see Figure 4) BBB endothelial ZO-1 expression and distribution is completely deregulated upon exposure to TS extract from 3R4F, NF and Ultralow Nicotine cigarettes

Virtual smokers are getting a smokeless nicotine dose delivered by the cigarette-style, tobacco-free device known generically as an e-cigarette