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[275] designed 2 lipid NPs, namely chondroitin sulfate-modified vismodegib-loaded NPs (CS-NPs/VDG) and glycyrrhetinic acid-modified silybin-loaded NPs (GA-NPs/SIB), which can target the repair of LSECs, inhibition of HSCs, and restoration of hepatocyte function, ultimately reversing liver fibrosis by regulating lipid oxidation and metabolic pathways

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