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The accumulation of NADH leads to a reduction in the coenzyme Q pool, and coupled with the malateaspartate shuttle, a surplus of fumarate accumulates and is then converted to succinate by the reverse catalysis of succinate dehydrogenase (SDH) [73, 74]

they can communicate information, sense danger when the cell energy levels drop, and are even involved in sending the final "death" message (apoptosis) when a cell is damaged beyond repair and needs to die

The ESI ionization mode was negative, and the MS scan range ( m/z ) was set to 65975