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"Based on currently available information (primarily from clinical trials), the types of side effects associated with ecnoglutide are expected to be similar to those of existing GLP-1 receptor agonists (such as semaglutide or dulaglutide), primarily including gastrointestinal disorders (diarrhea, nausea, vomiting) and decreased appetite

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22 Several other studies showed that there was no significant relationship between GLP-1 RAs and DR worsening, including one study by Joo et al in which manual review of the data was conducted to ensure accuracy in the ICD coding used to determine outcomes

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