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Medically reviewed by Alan Lucks | MD , Alan Lucks MDPC Private Practice - New York on January 1st, 2026

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It encompasses several pathways, including neurological (vagus nerve), hormonal, immunological, and microbiome-mediated signals, all of which play a critical role in maintaining physiological homeostasis and responding to systemic stresses (Sasso et al., 2023)

Figure 1 3 Ferroptosis-related proteins in TNBC progression Cannabinoid receptor 1 (CB1) is an important category of G protein-coupled receptors involved in mood regulation, cognitive function, and cell fate regulation ( Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) was highly expressed in TNBC and negatively correlated with prognosis ( Figure 2 )