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There were no significant changes in hematological, hepatic, renal, or cardiac markers following administration of the methanolic leaf extract at 2,000 mg/kg (223)

Separating administration by at least 24 hours is a conservative approach some providers recommend, though evidence-based guidelines remain limited

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Reactions of this type are more often related to preservatives in some solutions than to the vitamin itself, which is why we use high-quality formulations

In eleven instances (85%), the onset occurred during infancy