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While the beneficial effects of low IGF-1 action on aging seems well supported by data in model systems 6,7 and unique human populations 13,16 , a broader examination of the literature suggests that a more nuanced, complex, and controversial relationship exists between IGF-1, aging, and disease, which is indicative of the pleiotropic actions attributed to IGF-1 in cells and tissues 12,19

These molecular changes underlie visible structural regeneration in muscle tissue

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[DOI] [PubMed] [Google Scholar] 131.Sandoval D.A., Bagnol D., Woods S.C., DAlessio D.A., Seeley R.J

This was possibly due to GH inducing local production of IGF-I and binding proteins then maintaining a serum pool of IGF-I (8)